Earthpharm Technologies

Earthpharm NPDE

The Natural Product
Discovery Engine.

A botanical source can show an effect without showing which molecule is responsible.

That is a chemistry problem, and it is the one NPDE is being built to close.

Six stages

Inventory, then structure, then biology, then the bench.

  1. Chemical inventory

    Mass spectrometry of the source, to list what is there.

  2. Structure elucidation

    Identify each compound's structure.

  3. Target and pathway prediction

    Predict which targets and pathways each compound acts on (pharmacodynamics).

  4. Developability, corrected

    Predict absorption and safety (pharmacokinetics), with models corrected for natural-product chemistry.

  5. Indication-specific ranking

    Rank candidates against the biology of the disease.

  6. Bench confirmation

    Test the top candidates in the lab, and feed every result back into the ranking.

What is built, and what is being built

Built
The workflow, and the multi-target panel across eight upstream targets. It produced the target map behind EP-001.
In progress
The compound inventory, the natural-product correction layer, and the scoring model trained on our own bench results.

A workflow that runs is not the same as a model that has learned, and we will not describe one as the other.

A prediction is a hypothesis

It is not evidence of binding, and it is not evidence of efficacy.

Every candidate NPDE ranks goes to the bench first, and we report which predictions held and which did not.

Binding profiles, scoring methodology and per-target mechanistic detail are available under NDA.

Ownership

The measured natural-product dataset NPDE is calibrated on is generated on Earthpharm material, at Earthpharm’s cost, and is owned by Earthpharm Technologies Private Limited.

See the evidence package The science

Identities are coded pending patent filings. Available under NDA.